My holy grail has always been the ever popular 1909 S VDB Lincoln Cent.  I've owned three of them in my 41 years of collecting.  I just bought a PCGS VF20 example which I'll be recieving in December...  My next holy grail coin will be an 1877 Indian Cent in a grade that I can't afford

My Holy Grail is my collection. I cannot pick one. This question has been asked at least 20 times. Pick up your favorite coin. Not the one of most value.. Then pick up another. The more you do this the more you like them all. Each one has its she appeal. That's why you buy it. What will you do with the ones that are not your holy grail? Just like them.  If course you like them all. Just to be able to collect is the holy grail!!

I have no holly grail peice, but I do have a few coins that I have interests in and would not mind aquiring.  I would like a nice Jewish Revolt BCE 67 Silver Sheckle.  I would like a MS64+ 1936 New Zeeland Six Pence.  I would like a 1672 Dutch Seize coin.  I would like a couple of decent 1909 quarter eagles.  I would like a MS66+ Type 1 1913 Buffalo Nickel with an early die state.

Other things interest me as well.  I've take a liking to  Dutch Scheepjes Schelling from the 17th and 18th century.

@Mike
My Holy Grail is my collection. I cannot pick one. This question has been asked at least 20 times. Pick up your favorite coin. Not the one of most value.. Then pick up another. The more you do this the more you like them all. Each one has its own appeal. That's why you buy it. What will you do with the ones that are not your holy grail? Just like them.  If course you like them all. Just to be able to collect is the holy grail!!